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In today’s technologically driven world there is access to more information now than ever before, but navigating through the abundance of material available can be incredibly overwhelming and time consuming. With just a few keystrokes in a search engine you can find facts on any topic imaginable. Information and facts, however, are not enough to indefinitely sustain a business. There must be knowledge. Knowledge is born when facts and information come together to create a deep understanding of an idea, concept, principle, model, or design—the type of understanding that helps the individual, company, or corporation to make decisions that produce long-term growth and productivity.

At JPMCenter.LLC, we believe knowledge is invaluable. It informs us, challenges us, and helps us build on our talents, but acquiring knowledge takes time.

At JPMCenter.LLC we value and respect your time. Each of the materials, products, and services is designed to be accessible any time and any place. Our goal is to help you implement the knowledge you need on your own schedule.

We focus on equipping men and women in business with the information and tools necessary to gain the knowledge they need to keep their business healthy and growing. We don’t make get rich schemes or make broad guarantees. What we do promise is access to content generated by experts and industry professionals and tailored specifically to help businessmen and businesswomen grow as informed leaders. 

We will soon be announcing the posting of an updated site on Knowledge Transfer: drjp.com

Contact us via drjohn@jpmcenter.com if you wish to know more about us and particularly about our Knowledge Transfer Platform.

100 years old will be the new 60

By Peter Diamandis, PhD, MD.

This posting is Dr. Diamandis email sent to me shortly ago’

For the first time in history, leading scientists and entrepreneurs believe there’s a way to slow aging — and maybe even reverse it.The latest research on longevity suggests there is no reason that people born today can’t live to at least 120 years old… perhaps even to 150 and beyond.How would you change your life if you could live to 120 years old and remain healthy?What would you do differently today?Last week we explored the “Longevity Mindset.” Today and next week, I’ll do a quick review of the latest advancements toward rewiring the biology of aging. Every year, I take a group of my Abundance 360 Members on a “Platinum Longevity Trip” to meet with the cutting-edge researchers and companies. Following are some of the companies and technologies we observed that have the potential to increase your healthspan — the amount of time you have to live a healthy and functional life, avoiding expensive end-of-life care.

Over the past two decades, the cost of sequencing the human genome has dropped 100,000-fold: from $100 million per genome, to below $1,000 per genome (current estimates are as low as $300)
Genome sequencing can uncover disease susceptibilities years before symptoms present, allowing for personalized preventative care to begin sooner than ever before. 
For example, the Cancer Genome Atlas Program at the NIH is currently using gene sequencing to decode the genetic underpinnings of 30 cancer types.
Perhaps the most impactful potential of low-cost genome sequencing is its ability to be used in what is called a liquid biopsy — the ability to find free-flowing cancer DNA in your bloodstream that might indicate the existence of an undetected cancer in your body.  And, as we know, finding cancer at stage-zero or stage-one is the key to survival. 
There are two major companies we visited with during our Platinum Longevity Trip:
Cancer detection company GRAIL analyzes the mutated, fractionated DNA and RNA from cancer cells in your blood (from a simple blood draw) to diagnose over 50 cancer types in early stages. GRAIL recently received an $8 billion buy-out offer from biotech giant Illumina.
Freenome takes a similar approach to early cancer diagnosis from a real-time blood draw (called a liquid biopsy), initially focused on colon cancer. Freenome’s multiomics platform analyzes fragments of DNA, RNA, and protein from the cancer and from the host response. This form of precision medicine bridges early detection and early intervention to boost human healthspan. 

Gene Therapy
One of the most powerful technologies now available in the fight for longevity is called gene therapy — a technology theorized in the 1980s that has taken almost 40 years to mature. Gene therapy allows scientists to use a vector (typically an Adeno Associated Virus) to carry a desired gene to a set of desired cells in an organism. Want a specific gene put into retinal cells, or bone marrow, or neurons? No problem, there’s a gene therapy approach for that.
A new biotech start-up called Gordian Biotechnology is using the convergence of gene therapy and single cell sequencing to run hundreds of thousands of independent experiments in a single animal to determine the therapeutic effects of specific gene additions on specific cells of interest. Because aging is such a multifactorial process, this approach can run thousands of parallel experiments to tackle the many complexities of age-related diseases simultaneously. 
Next week, we’ll learn about a company called Rejuvenate Bio, and an extraordinary researcher named Dr. David Sinclair who is using gene therapy to potentially rejuvenate animals with the ultimate goal of age reversal in humans.

CRISPR: Cut, Paste, and Search Your Genes 
In addition to Gene Therapy, the other incredible tool in our longevity research arsenal is CRISPR. 
You may know CRISPR as the molecular scissors that can edit genes — think CTRL X (cut) and CTRL V (paste). But beyond cutting and pasting, CRISPR can also be used to help find and identify a sequence of DNA in your cell, sort of a “CTRL F” functionality. This discovery is so important and transformative that the Nobel Prize was just awarded this month to Dr. Jennifer Doudna of Gladstone Institutes for its discovery.
Here are several other exciting CRISPR developments:

Gladstone-UCSF Institute of Genomic Immunology is using CRISPR to edit the T-cells of the immune system that play critical roles in cancer, infection, and autoimmunity. CRISPR can delete mutated genes or add new DNA to reprogram the T-cells. This personalized approach takes advantage of the body’s own immune system to tackle complex diseases. 
Rather than snipping and replacing genes, Mammoth Biosciences has programmed CRISPR proteins to locate and cleave target genes, acting as “molecular shredders.” The cleaved gene serves as a molecular readout if the target is successfully bound, enabling CRISPR to serve as a diagnostic tool. Additionally, the company’s novel CRISPR proteins (cas14, casV) exist in the micro and nano scales, opening the door for new delivery systems at smaller scales than ever before.
With the recent breakthroughs in CRISPR and Gene Therapy technologies, a variety of strategies for reversing disease have been tried. Yet countless experiments remain, and that’s where AI can help.

Artificial Intelligence: Catalyzing Discovery 
The explosion of novel imaging, sensing, and sequencing tools has unleashed an abundance of patient data. 
But bringing together this information across millions of patients to form actionable insights can only be achieved with Artificial Intelligence. 
One of the leading companies in this area is Insilico Medicine, which is leveraging AI in its end-to-end drug pipeline, extending healthy longevity through drug discovery and aging research. 
In their comprehensive drug discovery engine, Insilico uses millions of samples and multiple data types to A) discover signatures of diseases, and B) identify the most promising targets for billions of molecules. These molecules either already exist or can be generated de novo with the desired set of parameters.
Insilico uses an AI technique called generative adversarial networks (GANs) to “imagine” novel molecular structures. With reinforcement learning, Insilico’s system lets you generate a molecule with any of up to 20 different properties to hit a specified target.
Thanks to converging breakthroughs in machine learning, drug discovery and molecular biology, companies like Insilico can now do with 50 people what the pharmaceutical industry can barely do with an army of 5,000.
Another extraordinary company on the Longevity Platinum Trip was a company out of the Buck Institute called Edifice Health, which has developed the ability to determine your “inflammatory age” using advanced AI to score biomarkers of immune health. Inflammation is a leading contributor to most chronic illnesses, and greater awareness of this symptom will enhance preventative care. Even more important than measuring inflammatory age, Edifice Health is screening thousands of molecules to determine which can quell such inflammation.
An additional company out of the Buck Institute is Gerostate Alpha, a pharmaceutical company that is using large-scale AI to test millions of compounds for their ability to extend the life of a worm-like creature called the nematode. Once they get a hit in nematodes (rather short-lived creatures), they will then test the molecules in mice and eventually in humans. The company is testing millions of compounds in parallel, hoping to literally discover the pharmaceutical fountain of youth. 
In next week’s blog, we’ll continue to review other exciting companies on the cutting-edge of longevity science, diving more into gene therapy, senolytic medicines, vaccines, and stem cells.

Join Me at Abundance 360
If tracking the latest breakthroughs in longevity is something you desire… If developing a Longevity Mindset is important to you, then consider joining my Abundance 360 Mastermind. 
Every year, my team and I select a group of 360 entrepreneurs and CEOs to coach over the course of a year-long program. A360 starts each January with a live event and continues every two months with Implementation Workshops, in which I personally coach members in small groups over Zoom. (In January 2021, you have a choice of live “in-person” or “virtual” participation. See the A360 website for more info.)
My mission is to help A360 members identify their massively transformative purpose, select their moonshot, and hone an Abundance, Exponential, and Longevity Mindset. Together we will actively select and reinforce your preferred mindsets.

To learn more and apply, visit abundance360.com
 

What Jobs, Jobs, Jobs Really Means in the 21st Century

By Dr. John Psarouthakis, Executive Editor

As measured by the calendar, America entered a new century and a new millennium a couple decades ago.
Delineating a new epoch is not that easy. The next few decades will reveal true, and perhaps game-changing, measurements of where the United States stands. The benchmarks
will be our global status as a developer of new technology, as
a smart manufacturer of value-added products, as an education reformer amid new workplace realities, and as a competitor in the global marketplace. Those are the four vectors of
our national future—“vector” being a better term than benchmark because a vector signals dynamic movement rather than
a mere static measurement. These four vectors—in technology, manufacturing, education, and globalization—will play
recurring roles in this narrative. They will determine whether
we enjoy further generations as a prosperous world leader,
or something less but close to that, or something you would
rather not think about—something your children and grandchildren definitely would rather not think about.
This truly is a new epoch, or era, or age (take your pick)
that we have entered, or are entering, or are about to enter.
Aldous Huxley, in Brave New World, drew the American Century’s entry point not at the year 1900 but at Henry Ford’s
first assembly line. I don’t know exactly where historians and
novelists and philosophers will draw our new high-tech journey’s embarkation point, and whether it will be as starkly definitive as old Henry’s delivery of durable goods and mobility
to the masses.

–For my book on this topic please click on www.jpmcenter.com

I do know that the new world now upon us is even more
amazing, but that as someone said in show business, we “ain’t
seen nothin’ yet.” I know technology has been the driving
force of change, as is almost always the case—from the discovery of fire to the personal computer. I know America’s
standing as a technological innovator has kept us in the game
as this new era begins, but technology alone cannot keep us
there, and innovation is itself vulnerable to rapid decline. In
other words, of all the “tipping points” one hears about, this is
the big one: Will the United States prevail in this new age, or
will it merely endure? And if it merely endures, how well will
it endure? And, by the way, might we be in danger of not even
enduring, at least not in any prosperous way we have come to
expect? Most importantly, what proactive steps must we take
to give ourselves hope for sustaining a competitive edge, perhaps enough to forge another American Century?
That challenge is what The Technology Imperative in this book
this book and our nation’s future—is about. First, however,
I need to offer some thoughts about policy and politics, because all the above questions—and all the answers, mine and
yours and anyone else’s—will be irrelevant unless and until
the problems discussed in this chapter are defined, addressed,
and solved. If you find that prospect daunting, consider this:
The one institution that must solve these problems is itself the
biggest problem that must be solved. Our intransigent, dysfunctional, gridlocked, elected federal government must ride
to the rescue of itself. It is as if your town council met once a
week discussing old business in perpetuity without acting on
the problems and on the possible solutions, meanwhile ignoring vital new agenda items. Tip O’Neill,
one of the 20th Century’s consummate politicians, famously
said that all politics is local. Sorry, Tip, but any local government that bundled misfeasance, malfeasance and nonfeasance
into such an ineffectual package would be driven from office
this very evening.
Washington’s logjam of problematical old business cannot
be addressed by mere political promises. Most of these problems in fact are political promises run amok—the multi $-trillionand-growing national debt being the perfect example. The 537 men and women we elect to national office fiddled while these problems reached critical mass. Now these politicians have the power to let 320 million Americans enter the new epoch and compete…or the power to be 537 dinosaurs dragging
us into history’s tar pit.
I want to be an optimist about which choice our elected
officials will make, but my experience watching politicians at
work—most especially groups of politicians at work—suggests all bets should be hedged. The first company I founded
was operating successfully in five countries when I divested
my interest. Earlier, as an executive for another company, I
conducted corporate business in several nations—often establishing that company’s footprint in a new global outpost. I
have been a guest lecturer at major universities in Scotland,
the Netherlands, and Germany. I have enjoyed decades of
world travel and observation, and how can one observe a
place without observing its politics? In one of the most beautiful regions on earth, my native land, I have stayed in touch
with friends and associates struggling endlessly in an effort to
forge a competitive society and economy while their political
institutions push in the opposite direction. In case you haven’t
guessed, Psarouthakis is a Greek name.
4 The Technology Impera ve
My observation has been that politicians, be they Greeks
or Germans or Michiganders, share a pre-eminent trait. No
matter what happens around them they will act to pursue their
political interest, which primarily is to get elected. And reelected. And re-elected again. If making a crucial decision
would mean constituents must feel some pain (real or imagined), then that decision gets pushed aside. If an officeholder’s
constituents are split down the middle on a crucial issue, then
that issue gets pushed aside. If it seems a crucial issue can
be kicked down the road for years until the politician retires
and someone else must deliver unwanted news to voters, then
that issue gets ignored time and time again. If a crucial issue
is one on which party leaders (and their re-election machine)
demand a lockstep vote, then that issue gets a lockstep vote.
Traditionally, the “pressing” part of “this is a pressing issue” managed to get things accomplished in Washington. The
fringes on left or right made their points, sometimes even
serving as the cutting edge of progress. But the center would
hold, common ground would be found, and the nation was
governed. In recent years the political center has been overcome by a flood of ideological purity from either side, the
eternal quest for re-election has become more time-consuming, and new media have put our politicians onstage every
moment of the day. The result? Our government has become
so dysfunctional one would think Washington is not the capital of the world’s last superpower, but a Peter Sellers comedy
set in one tiny duchy or another—except that, unlike a Peter
Sellers movie, these people are not amusing. Each election
day one hopes the lunacy has gone away and some business
will get done. Instead, the new election cycle begins the day
after the previous election cycle.
This manuscript was written in the first half of 2012, an
ar of he problem and par of he solu on 5
election year, a noisy time that only amplifies the irrationality, the refusal to take serious business seriously, to a deafening level. One day, while thinking about how best to discuss
profound challenges raised by the new technological age and
the global economy, I took a break and turned on television
news. I found one political party’s presidential contenders
bickering about birth control and the sitting president of the
United States squandering a ripe opportunity to move the nation toward energy self-sufficiency (mocking his supposedly
anti-green political foes while at the same time telling Brazil
to drill, baby, drill). No wonder the pundits often try to make
sense of this circus by asking who is the smart person in the
room–or, even more telling, who is the adult in the room?
Turning on TV news most anytime will also, within a minute or two, produce a politician chanting “Jobs! Jobs! Jobs!”
In today’s climate that chant somehow passes for intelligent
discourse. It is not. It’s political pandering, albeit effective
pandering, which is why both parties loudly indulge the same
chant. Of course we all want every American to have a livelihood and the best possible job. The real test of that chant has
nothing to do with political push-me, pull-you rhetoric about
whether the economy can best be grown by raising taxes or
by lowering taxes. The real test lies in the 21st Century vectors cited in this chapter’s first paragraph—none of which can
be addressed until Congress and the White House clean up
their unfinished business. Keep in mind that image of a town
council playing and replaying “Groundhog Day.” If any smart
adults are in that room they are in a minority, and clearly none
has the capacity to lead the kids in the room toward rational
action.
The future of American jobs, and fundamental change in
the workforce, is the ultimate subject of this book. In the end